Waste incineration is an alternative way of heating, which can reduce the dependence on fossil fuels and carbon dioxide emissions, but the elements such as S and Cl present in the waste incineration process affect the use of boiler pipes. With the increase of temperature, the hot corrosion phenomenon is intensified, and the hot end pipe component damage is also aggravated, which may cause catastrophic accidents. Therefore, the corrosion resistant protective coating on superheater tube is an effective method to solve this problem. The Fe-based amorphous coating (AMC) has the advantages of low cost and strong corrosion resistance: Firstly, the Fe-based AMC uses Fe-based multi-metallic materials as raw materials, which has lower cost than other kinds of amorphous materials; moreover, this kind of coating has excellent anti-corrosion, wear-resistant and easy to repair. Herein, a novel Fe-based AMC were prepared on 316L stainless steel substrate by detonation spraying technology. The corrosion behavior of AMC coating/316L stainless steel covered with deposit of 2 mg/cm² mixed salts of either K₂SO₄ + 50%Na₂SO₄ or NaCl + 50%Na₂SO₄ (in mass fraction) was assessed at 450 and 550 ^oC in air respectively. Results indicate that the coating exhibited good resistance to mixed salts corrosion superior to that of 316L stainless steel substrate. After mixed salts corrosion at 450 ^oC for 90 h, the coating showed slight corrosion and formation of minimal corrosion products. After corrosion at 550 ^oC, the coating surface became rougher with visible cracking. The corrosion impact of NaCl + 50%Na₂SO₄ on the coating was found to be more severe than that of K₂SO₄ + 50%Na₂SO₄. This is primarily due to the reaction of NaCl with the oxide layer on the coating surface; leading to the formation of Cl₂. Cl₂ can penetrate the formed oxide scale, react with the uncorroded coating, induce cracks in the oxide scale, and finally accelerate the corrosion process of the coating.