Mo-alloys are widely used in high-temperature environments foraerospace, nuclear energy and nuclear power industries due to their high melting point, excellent electrical and thermal conductivity and outstanding high-temperature mechanical properties. However, Mo-alloys are very susceptible to oxidation and failure in high-temperature service environments. In this study, Si-ZrB₂-Ti-Cr multicomponent anti-oxidation coatings were fabricated on Mo-alloys via laser cladding, and the effect of laser power on themicrostructure, phase composition, and high-temperature oxidation resistance of the acquired coatings was systematically investigated. The results show that when the laser power for cladding is 2000 W, the main constituents of the coating is metastable Mo₅Si₃ phase rather than the stable MoSi₂ phase, the metastable Mo₅Si₃ phase tens to generate MoO₃ during high-temperature oxidation process, which is highly volatile,, thus the coating has poor oxidation resistance. When the laser power is 3000 W, the acquired coating is ~900 μm in thickness, which showed the best oxidation resistance at 1200 ^oC with formation of a dense oxide scale on surface composed of SiO₂, TiO₂, and ZrO₂. As the laser power was increased to 4500 W, the excessive heat input caused too much Mo to be incorporated into the coating from the substrate. During the oxidation process MoO₃ was prone to volatilize, making the oxide scale porous and loose, thereby reducing the oxidation resistance. These findings may provide a reference for further R & D of high-temperature protective coatings on Mo-alloys.